A Clinical Commentary on the Articles “Strategies for Tissue Engineering Cardiac Constructs to Affect Functional Repair Following Myocardial Infarction” and “Stem Cell-Based Cardiac Tissue Engineering”
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چکیده
منابع مشابه
Strategies Affording Prevascularized Cell-Based Constructs for Myocardial Tissue Engineering
The production of a functional cardiac tissue to be transplanted in the injured area of the infarcted myocardium represents a challenge for regenerative medicine. Most cell-based grafts are unviable because of inadequate perfusion; therefore, prevascularization might be a suitable approach for myocardial tissue engineering. To this aim, cells with a differentiation potential towards vascular an...
متن کاملRole of Stem Cells in Cardiac Cell Therapy and Tissue Engineering
Background: In spite of promising results of conventional treatments for myocardial infarction, including medications, stent implantation, and coronary artery bypass grafting, the disease and its complications, especially heart failure, are highly prevalent because these methods could not reverse the cell loss, which is the main problem. Currently, heart transplantation, as the last option f...
متن کاملManufacturing a Biomimetic Biorecator in Cardiac Tissue Engineering
Introduction: The direct approach of cardiac tissue engineering is to mimic the natural tissue of heart, considering the significant role of scaffolding and mechanical simulation. Methods: To achieve this purpose, a composite Polycaprolactone (PCL)/Gelatin electrospun scaffold with a ratio of 70:30 and with the most similarities to the cardiac extracellular matrix was fabricated with aligned ...
متن کاملInjectable cardiac tissue engineering for the treatment of myocardial infarction
Future perspectives Heart disease is a leading cause of morbidity and mortality worldwide. Myocardial infarction leads to permanent loss of cardiac tissue and ultimately heart failure. However, current therapies could only stall the progression of the disease. Thus, new therapies are needed to regenerate damaged hearts to overcome poor prognosis of patients with heart failure. The shortage of h...
متن کاملTissue engineering and stem cell therapy for myocardial repair.
Cardiovascular disease is a major public health problem in the United States. In many survivors, extensive tissue damage from myocardial infarction leads to the development of congestive heart failure. Unfortunately, thus far, heart transplantation has remained the only viable treatment for end-stage congestive heart failure. Lack of available donor hearts has thus led to search for alternative...
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ژورنال
عنوان ژورنال: Journal of Cardiovascular Translational Research
سال: 2011
ISSN: 1937-5387,1937-5395
DOI: 10.1007/s12265-011-9295-x